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Microbiome subsets determine tumor prognosis and molecular characteristics of clear-cell renal cell carcinoma: a multi-center integrated analysis of microbiome, metabolome, and transcriptome data

《医学前沿（英文）》 doi: 10.1007/s11684-023-1029-3

摘要： Microbiome subsets determine tumor prognosis and molecular characteristics of clear-cell renal cell carcinoma: a multi-center integrated analysis of microbiome, metabolome, and transcriptome data

关键词： tumor prognosis molecular     Microbiome subsets determine     center analysis microbiome     transcriptome data    

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Integrated analysis of gut microbiome and host immune responses in COVID-19

《医学前沿（英文）》 2022年 第16卷 第2期   页码 263-275 doi: 10.1007/s11684-022-0921-6

摘要： Emerging evidence indicates that the gut microbiome contributes to the host immune response to infectious diseases. Here, to explore the role of the gut microbiome in the host immune responses in COVID-19, we conducted shotgun metagenomic sequencing and immune profiling of 14 severe/critical and 24 mild/moderate COVID-19 cases as well as 31 healthy control samples. We found that the diversity of the gut microbiome was reduced in severe/critical COVID-19 cases compared to mild/moderate ones. We identified the abundance of some gut microbes altered post-SARS-CoV-2 infection and related to disease severity, such as Enterococcus faecium, Coprococcus comes, Roseburia intestinalis, Akkermansia muciniphila, Bacteroides cellulosilyticus and Blautia obeum. We further analyzed the correlation between the abundance of gut microbes and host responses, and obtained a correlation map between clinical features of COVID-19 and 16 severity-related gut microbe, including Coprococcus comes that was positively correlated with CD3+/CD4+/CD8+ lymphocyte counts. In addition, an integrative analysis of gut microbiome and the transcriptome of peripheral blood mononuclear cells (PBMCs) showed that genes related to viral transcription and apoptosis were up-regulated in Coprococcus comes low samples. Moreover, a number of metabolic pathways in gut microbes were also found to be differentially enriched in severe/critical or mild/moderate COVID-19 cases, including the superpathways of polyamine biosynthesis II and sulfur oxidation that were suppressed in severe/critical COVID-19. Together, our study highlighted a potential regulatory role of severity related gut microbes in the immune response of host.

关键词： COVID-19     SARS-COV-2     gut microbiome     immune response    

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Comparative analysis of impact of human occupancy on indoor microbiomes

《环境科学与工程前沿（英文）》 2021年 第15卷 第5期 doi: 10.1007/s11783-020-1383-1

摘要：

• Exposure to indoor microbiomes is a public health concern in educational facilities.

关键词： Built environment     Indoor microbiome     Occupant     Building     Sequencing    

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微生物组分析技术的发展趋势：从单细胞功能成像到菌群大数据

徐健, 马波, 苏晓泉, 黄适, 徐欣, 周学东, 黄巍, Rob Knight

《工程（英文）》 2017年 第3卷 第1期   页码 66-70 doi: 10.1016/J.ENG.2017.01.020

摘要：

方法学创新一直是微生物组学研究的核心驱动力。我们认为在未来五到十年，微生物组的方法学体系在研究理念与技术平台方面将发生三大变革：①从监测菌群“结构”变化向监测菌群“功能/状态”变化的变革；②从细胞“群体”分析精度向细胞“个体”分析精度的转变；③从“数据分析”向“数据科学”的跨越。在这里我们针对实现上述三大方法学变革需要克服的关键科学或技术挑战，重点介绍了部分中国微生物组分析方法学研究团队及其国际合作伙伴的最新工作进展。我们相信中国微生物组计划应把握住当前这一重要机遇，通过在微生物组分析方法学前沿开展富有雄心、远见、创意与竞争力的交叉合作研究，为国际微生物组计划贡献一系列“中国制造”的新方法、新工具和新仪器。

关键词： 微生物组     方法学创新     单细胞分析     大数据     中国微生物组计划    

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Understanding building-occupant-microbiome interactions toward healthy built environments: A review

Shuai Li, Zhiyao Yang, Da Hu, Liu Cao, Qiang He

《环境科学与工程前沿（英文）》 2021年 第15卷 第4期 doi: 10.1007/s11783-020-1357-3

摘要： Abstract • The built environment, occupants, and microbiomes constitute an integrated ecosystem. • This review summarizes research progress which has focused primarily on microbiomes. • Critical research needs include studying impacts of occupant behaviors on microbiomes. Built environments, occupants, and microbiomes constitute a system of ecosystems with extensive interactions that impact one another. Understanding the interactions between these systems is essential to develop strategies for effective management of the built environment and its inhabitants to enhance public health and well-being. Numerous studies have been conducted to characterize the microbiomes of the built environment. This review summarizes current progress in understanding the interactions between attributes of built environments and occupant behaviors that shape the structure and dynamics of indoor microbial communities. In addition, this review also discusses the challenges and future research needs in the field of microbiomes of the built environment that necessitate research beyond the basic characterization of microbiomes in order to gain an understanding of the causal mechanisms between the built environment, occupants, and microbiomes, which will provide a knowledge base for the development of transformative intervention strategies toward healthy built environments. The pressing need to control the transmission of SARS-CoV-2 in indoor environments highlights the urgency and significance of understanding the complex interactions between the built environment, occupants, and microbiomes, which is the focus of this review.

关键词： Microbiome     Built Environment     Occupant     Health    

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Meter-scale variation within a single transect demands attention to taxon accumulation curves in riverine microbiome

《环境科学与工程前沿（英文）》 2022年 第16卷 第5期 doi: 10.1007/s11783-022-1543-6

摘要：

● Riverine microbiomes exhibited hyperlocal variation within a single transect.

关键词： Microbiome     Freshwater     Taxon accumulation curve     Community assembly    

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Human microbiome and prostate cancer development: current insights into the prevention and treatment

Solmaz Ohadian Moghadam, Seyed Ali Momeni

《医学前沿（英文）》 2021年 第15卷 第1期   页码 11-32 doi: 10.1007/s11684-019-0731-7

摘要： The huge communities of microorganisms that symbiotically colonize humans are recognized as significant players in health and disease. The human microbiome may influence prostate cancer development. To date, several studies have focused on the effect of prostate infections as well as the composition of the human microbiome in relation to prostate cancer risk. Current studies suggest that the microbiota of men with prostate cancer significantly differs from that of healthy men, demonstrating that certain bacteria could be associated with cancer development as well as altered responses to treatment. In healthy individuals, the microbiome plays a crucial role in the maintenance of homeostasis of body metabolism. Dysbiosis may contribute to the emergence of health problems, including malignancy through affecting systemic immune responses and creating systemic inflammation, and changing serum hormone levels. In this review, we discuss recent data about how the microbes colonizing different parts of the human body including urinary tract, gastrointestinal tract, oral cavity, and skin might affect the risk of developing prostate cancer. Furthermore, we discuss strategies to target the microbiome for risk assessment, prevention, and treatment of prostate cancer.

关键词： microbiome     prostate cancer     prevention     treatment     molecular pathological epidemiology (MPE)     biomarker    

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Dual-reaction-center catalytic process continues Fenton’s story

Chao Lu, Kanglan Deng, Chun Hu, Lai Lyu

《环境科学与工程前沿（英文）》 2020年 第14卷 第5期 doi: 10.1007/s11783-020-1261-x

摘要： Abstract • Dual-reaction-center (DRC) system breaks through bottleneck of Fenton reaction. • Utilization of intrinsic electrons of pollutants is realized in DRC system. • DRC catalytic process well continues Fenton’s story. Triggered by global water quality safety issues, the research on wastewater treatment and water purification technology has been greatly developed in recent years. The Fenton technology is particularly powerful due to the rapid attack on pollutants by the generated hydroxyl radicals (•OH). However, both heterogeneous and homogeneous Fenton/Fenton-like technologies follow the classical reaction mechanism, which depends on the oxidation and reduction of the transition metal ions at single sites. So even after a century of development, this reaction still suffers from its inherent bottlenecks in practical application. In recent years, our group has been focusing on studying a novel heterogeneous Fenton catalytic process, and we developed the dual-reaction-center (DRC) system for the first time. In the DRC system, H2O2 and O2 can be efficiently reduced to reactive oxygen species (ROS) in electron-rich centers, while pollutants are captured and oxidized by the electron-deficient centers. The obtained electrons from pollutants are diverted to the electron-rich centers through bonding bridges. This process breaks through the classic Fenton mechanism, and improves the performance and efficiency of pollutant removal in a wide pH range. Here, we provide a brief overview of Fenton’s story and focus on combing the discovery and development of the DRC technology and mechanism in recent years. The construction of the DRC and its performance in the pollutant degradation and interfacial reaction process are described in detail. We look forward to bringing a new perspective to continue Fenton’s story through research and development of DRC technology.

关键词： Dual reaction centers     Fenton     Pollutant utilization     Electron transfer    

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基于人体髋关节转动中心分析的髋关节外骨骼仿生设计 Article

Wei YANG,Can-jun YANG,Ting XU

《信息与电子工程前沿（英文）》 2016年 第17卷 第8期   页码 792-802 doi: 10.1631/FITEE.1500286

摘要： 为了改善外骨骼穿戴舒适性，本文提出了一种基于人机物理交互优化的外骨骼设计方法。该方法通过设计外骨骼髋关节，使其保证人体髋关节运动时外骨骼髋关节转动中心能跟随人体髋关节转动中心的运动轨迹。当人体髋关节运动时，通过实验测量和计算可以得到其转动中心轨迹。本文设计的外骨骼髋关节运动机构能在人体髋关节屈曲/伸展和外展/内收时，保证转动中心都能够包容人体髋关节转动中心运动范围。同时，所设计的外骨骼髋关节被应用到下肢步行康复训练外骨骼中。通过人机接触力实验可知，与传统设计外骨骼髋关节进行相比，本文设计的仿生髋关节外骨骼在髋关节屈曲/伸展和内收/外展时分别可以减小24.1%和76.0%的人机接触力。这一结果证明仿生设计髋关节外骨骼更具穿戴舒适性，更符合人机工程学的设计要求。最后，本文通过建立人机闭式链模型进一步分析了仿生设计对于人体髋关节内力的影响，并验证该设计能减少关节内力作用。

关键词： 髋关节外骨骼；髋关节中心；柔顺关节；人机交互力    

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Meter-scale variation within a single transect demands attention to taxon accumulation curves in riverine microbiome

《环境科学与工程前沿（英文）》 2022年 第16卷 第6期 doi: 10.1007/s11783-022-1560-5

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Air bearing center cross gap of neutron stress spectrometer sample table support system

Yang LI,Yunxin WU,Hai GONG,Xiaolei FENG

《机械工程前沿（英文）》 2016年 第11卷 第4期   页码 403-411 doi: 10.1007/s11465-016-0405-y

摘要：

A support system is the main load-bearing component of sample table for neutron stress spectrometer, and air bearing is an important element of a support system. The neutron stress spectrometer sample table was introduced, and the scheme for air bearing combination was selected. To study the performance of air bearing center cross gap, finite element models (FEMs) were established based on air motion and Reynolds equations, effects of air supply pressure, and gap parameters on the overturning moment and bearing capacity of air bearing center cross gap were analyzed. Results indicate that the width, depth, and height differences of the marble floor gap played important roles in the performance of the air bearing. When gap width is lesser than 1 mm and gap depth is lower than 0.4 mm, bearing capacity and overturning moment would vary rapidly with the variation of the width and depth. A gap height difference results in the bearing capacity dropping rapidly. The FEM results agree well with experimental results. Further, findings of the study could guide the design of the support system and marble floor.

关键词： neutron stress spectrometer     sample table     support system     air bearing     center cross gap     simulation     experiment    

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Chinese medicine patterns on older patients with chronic obstructive pulmonary disease: a subgroup analysisfrom a four-center, randomized, controlled study

null

《医学前沿（英文）》 2014年 第8卷 第3期   页码 368-375 doi: 10.1007/s11684-014-0360-0

摘要：

This study aimed to evaluate the efficacy of comprehensive therapy based on traditional Chinese medicine (TCM) patterns on older patients with chronic obstructive pulmonary disease (COPD) through a four-center, open-label, randomized controlled trial. Patients were divided into the trial group treated using conventional western medicine and Bu-Fei Jian-Pi granules, Bu-Fei Yi-Shen granules, and Yi-Qi Zi-Shen granules based on TCM patterns respectively; and the control group treated using conventional western medicine. A total of 136 patients≥65 years completed the study, with 63 patients comprising the trial group and 73 comprising the control group. After the six-month treatment and the 12-month follow-up period, significant differences were observed between the trial and control groups in the following aspects: frequency of acute exacerbation (P≤0.040), duration of acute exacerbation (P = 0.034), symptoms (P≤0.034), 6-min walking distance (6MWD) (P≤0.039), dyspnea scale (P≤0.036); physical domain (P≤0.019), psychological domain (P≤0.033), social domain (P≤0.020), and environmental domain (P≤0.044) of the WHOQOL-BREF questionnaire; and daily living ability domain (P≤0.007), social activity domain (P≤0.018), depression symptoms domain (P≤0.025), and anxiety symptoms domain (P≤0.037) of the COPD-QOL. No differences were observed between the trial and control groups with regard to FVC, FEV1, and FEV1%.

关键词： chronic obstructive pulmonary disease     older adult     clinical trial     Bu-Fei Jian-Pi granules     Bu-Fei Yi-Shen granules     Yi-Qi Zi-Shen granules    

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Design and modeling of continuum robot based on virtual-center of motion mechanism

《机械工程前沿（英文）》 2023年 第18卷 第2期 doi: 10.1007/s11465-022-0739-6

摘要： Continuum robot has attracted extensive attention since its emergence. It has multi-degree of freedom and high compliance, which give it significant advantages when traveling and operating in narrow spaces. The flexural virtual-center of motion (VCM) mechanism can be machined integrally, and this way eliminates the assembly between joints. Thus, it is well suited for use as a continuum robot joint. Therefore, a design method for continuum robots based on the VCM mechanism is proposed in this study. First, a novel VCM mechanism is formed using a double leaf-type isosceles-trapezoidal flexural pivot (D-LITFP), which is composed of a series of superimposed LITFPs, to enlarge its stroke. Then, the pseudo-rigid body (PRB) model of the leaf is extended to the VCM mechanism, and the stiffness and stroke of the D-LITFP are modeled. Second, the VCM mechanism is combined to form a flexural joint suitable for the continuum robot. Finally, experiments and simulations are used to validate the accuracy and validity of the PRB model by analyzing the performance (stiffness and stroke) of the VCM mechanism. Furthermore, the motion performance of the designed continuum robot is evaluated. Results show that the maximum stroke of the VCM mechanism is approximately 14.2°, the axial compressive strength is approximately 1915 N/mm, and the repeatable positioning accuracies of the continuum robot is approximately ±1.47° (bending angle) and ±2.46° (bending direction).

关键词： VCM mechanism     continuum robot     flexural joint     pseudo-rigid body model     cable-driven    

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建筑物内火旋风中心飘移的探讨与研究

陈长坤,姚斌,范维澄

《中国工程科学》 2003年 第5卷 第10期   页码 63-68

摘要：

火旋风是火灾中一种较为特殊的火行为，是火灾安全研究的一个重要内容。针对建筑物内火旋风的行为进行研究，提出了一种用于描述和表征建筑物内火旋风中心飘移的分析方法。结合此方法，应用大涡模拟技术对火旋风中心飘移现象进行了数值模拟研究，得到了火旋风中心飘移的平均角速度、温度峰值、高温中心位置等重要参数。

关键词： 火旋风     中心飘移     大涡模拟     建筑    

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Antibiotics-mediated intestinal microbiome perturbation aggravates tacrolimus-induced glucose disorders

Yuqiu Han, Xiangyang Jiang, Qi Ling, Li Wu, Pin Wu, Ruiqi Tang, Xiaowei Xu, Meifang Yang, Lijiang Zhang, Weiwei Zhu, Baohong Wang, Lanjuan Li

《医学前沿（英文）》 2019年 第13卷 第4期   页码 471-481 doi: 10.1007/s11684-019-0686-8

摘要： Both immunosuppressants and antibiotics (ABX) are indispensable for transplant patients. However, the former increases the risk of new-onset diabetes, whereas the latter impacts intestinal microbiota (IM). It is still unclear whether and how the interaction between immunosuppressants and ABX alters the IM and thus leads to glucose metabolism disorders. This study examined the alterations of glucose and lipid metabolism and IM in mice exposed to tacrolimus (TAC) with or without ABX. We found that ABX further aggravated TAC-induced glucose tolerance and increased insulin secretion. Combined treatment resulted in exacerbated lipid accumulation in the liver. TAC-altered microbial community was further amplified by ABX administration, as characterized by reductions in phylum Firmicutes, family Lachnospiraceae, and genus . Analyses based on the metagenomic profiles revealed that ABX augmented the effect of TAC on microbial metabolic function mostly related to lipid metabolism. The altered components of gut microbiome and predicted microbial functional profiles showed significant correlation with hepatic lipid accumulation and glucose disorders. In conclusion, ABX aggravated the effect of TAC on the microbiome and its metabolic capacities, which might contribute to hepatic lipid accumulation and glucose disorders. These findings suggest that the ABX-altered microbiome can amplify the diabetogenic effect of TAC and could be a novel therapeutic target for patients.

关键词： antibiotics     tacrolimus     glucose disorders     microbiome    

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标题 作者 时间 类型 操作

Microbiome subsets determine tumor prognosis and molecular characteristics of clear-cell renal cell carcinoma: a multi-center integrated analysis of microbiome, metabolome, and transcriptome data

期刊论文

Integrated analysis of gut microbiome and host immune responses in COVID-19

期刊论文

Comparative analysis of impact of human occupancy on indoor microbiomes

期刊论文

微生物组分析技术的发展趋势：从单细胞功能成像到菌群大数据

徐健, 马波, 苏晓泉, 黄适, 徐欣, 周学东, 黄巍, Rob Knight

期刊论文

Understanding building-occupant-microbiome interactions toward healthy built environments: A review

Shuai Li, Zhiyao Yang, Da Hu, Liu Cao, Qiang He

期刊论文

Meter-scale variation within a single transect demands attention to taxon accumulation curves in riverine microbiome

期刊论文

Human microbiome and prostate cancer development: current insights into the prevention and treatment

Solmaz Ohadian Moghadam, Seyed Ali Momeni

期刊论文

Dual-reaction-center catalytic process continues Fenton’s story

Chao Lu, Kanglan Deng, Chun Hu, Lai Lyu

期刊论文

基于人体髋关节转动中心分析的髋关节外骨骼仿生设计

Wei YANG,Can-jun YANG,Ting XU

期刊论文

Meter-scale variation within a single transect demands attention to taxon accumulation curves in riverine microbiome

期刊论文

Air bearing center cross gap of neutron stress spectrometer sample table support system

Yang LI,Yunxin WU,Hai GONG,Xiaolei FENG

期刊论文

Chinese medicine patterns on older patients with chronic obstructive pulmonary disease: a subgroup analysisfrom a four-center, randomized, controlled study

null

期刊论文

Design and modeling of continuum robot based on virtual-center of motion mechanism

期刊论文

建筑物内火旋风中心飘移的探讨与研究

陈长坤,姚斌,范维澄

期刊论文

Antibiotics-mediated intestinal microbiome perturbation aggravates tacrolimus-induced glucose disorders

Yuqiu Han, Xiangyang Jiang, Qi Ling, Li Wu, Pin Wu, Ruiqi Tang, Xiaowei Xu, Meifang Yang, Lijiang Zhang, Weiwei Zhu, Baohong Wang, Lanjuan Li

期刊论文